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Parakil Plus Vet - Ivermectin - Incepta

Parakil Plus Vet is a veterinary medicine of the generic class Ivermectin and the Therapeutic Group of this veterinary medicine is Anthelmintic. Parakil Plus Vet is manufactured by Incepta Pharmaceuticals Limited. 

Source - Incepta

Composition

Parakil Plus vet Injection: Each ml injectable solution contains Ivermectin BP 10 mg &Clorsulon USP 100 mg.

Description

Ivermectin is a derivative of Avermectins, a family of potent broad-spectrum anthelmintic. Ivermectin binds selectively with high affinity to glutamate-gated chloride ion channels results in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, causing paralysis and death of the parasite. It is a reliable, long-lasting parasite controller of cattle for effective treatment and control of internal and external parasitic infections and for protecting animals from re-infection. Clorsulon is a drug of benzene sulphonamides family work as flukicide. Clorsulon kills parasites by inhibiting the enzymes involved in the glycolytic pathway, the primary source of energy of flukes. It also depresses the ATP level in the flukes.

Indications

Parakil Plus is indicated for the treatment, control, and protect the animal from re-infection of the following parasites-

Gastrointestinal Roundworms (adult and fourth-stage larvae): Ostertagiaostertagi, Haemonchusplacei, Trichostrongylusaxei, T. colubriformis, Cooperiaoncophora, C. punctata, C. pectinata, Oesophagostomumradiatum, Bunostomumphlebotomum, Nematodirushelvetianus (adults only) & N. spathiger (adults only).

Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparous

Grubs (parasitic stages): Hypodermabovis& H. lineatum

Sucking Lice: Linognathusvituli, Haematopinuseurysternus&Solenopotescapillatus

Mites (scabies): Psoroptesovis (syn. P. communis var. bovis) &Sarcoptesscabiei var. bovis

Liver fluke: Fasciola hepatica (Adults only)

Dosage & Administration

Injection Parakil Plus vet should be injected only by a subcutaneous route (under the loose skin in front of or behind the shoulder).

Cattle, buffalo, goat, sheep & horse: 1 ml/50 kg (Ivermectin 0.2 mg &Clorsulon 2 mg/kg) body weight (single injection). In the case of humpsore in cattle the dose may be repeated after 28 days.

Or as directed by the registered Veterinarian

Side Effects

The combination is well tolerated at recommended dose. However, a low incidence of soft tissue swelling at the injection site may be observed. These reactions will disappear without any treatment within 30 min-1 hours.

Precautions

This combination should not be used in an intravenous or intramuscular route.

Use in Pregnancy & Lactation

Safe in pregnant and lactating animals.

Drug Interaction

Barbiturates (such as Phenobarbital, Butalbital), benzodiazepines (such as Clonazepam, Diazepam, Lorazepam), Sodium Oxybate (GHB), and Valproic acid have drug interactions with Ivermectin injection. In that case, caution should be applied before using upper mentioned drugs.

OverDose

10 times safe in ruminants. However, hives, tingling of feet, weakness, loss of coordination, stomach pain, vomiting, diarrhea, difficult breathing may be reported.

Withdrawal Period

Meat: 21 days & Milk: Sufficient information is not available.
Storage
Do not store above 30°C, avoid freezing. Store the vial in the carton to protect from light. Keep out of the reach of children.

Commercial Pack

Parakil Plus vet Injection 10 ml: Each commercial box contains 1 vial of 10 ml.


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