Duozol DS Vet bolus - Triclabendazole 1800 mg & Levamisole 1200 mg

Source - Incepta

Composition

Duozol DS vet bolus: Each bolus contains Triclabendazole INN 1800 mg and Levamisole Hydrochloride BP equivalent to Levamisole 1200 mg.

Description

The combination of Triclabendazole and Levamisoleis used for the treatment and control of fascioliasis, gastro-intestinal roundworms, and lungworms in cattle, sheep, and goats. Triclabendazole inhibits energy metabolism and Levamisole inhibits neuromuscular transmission of helminths. Levamisole acts on the neuromuscular junctions of nerves of nematodes as a ganglionic nicotinic acetylcholine agonist, causing muscular contraction of the worm and stimulates the parasympathetic and sympathetic ganglia of susceptible worms. It also interferes with carbohydrate metabolism in nematodes by blocking fumarate reduction and succinate oxidation. The overall effect is paralysis of the worm, allowing it to be expelled.

Indications

The combination is a broad-spectrum anthelmintic used against helminths in cattle, buffalo, sheep, goat, etc. The drug is used for the treatment of acute, sub-acute, and chronic fascioliasis due to the early immature and adult stages of Fasciola hepatica &Fasciolagigantica. It is also used against major parasites of ruminants such as Haemonchus and Ostertagia of the abomasum; Cooperia, Trichostrongylus, and Bunostomum of the small intestine; Oesophagustomum, Trichuris of the large intestine &Dictyocaulus spp. of the lungs. It is also used for the treatment of eye worms (Thelazia) of cattle.

Dosage & Administration

1 bolus for 150-180 kg b.w. or Triclabendazole 12 mg &Levamisole 8 mg per kg b.w. animal.

Triclabendazole and Levamisole bolus to be administered directly into the mouth of the animals, either by dissolving the tablet in water or given as drench or by mixing with molasses or by wrapping the tablet in a banana leaf.

Or as directed by the registered Veterinarian

Side Effects

The combination is well tolerated at the recommended dose. The safety index of Triclabendazole is about 16 times and the safety index of Levamisole is about 3 times the recommended dosage. But the safety index of a combination of Triclabendazole&Levamisole is 3 times the recommended dose.

Precautions

Adequate water should be fed during and after therapy.

Use in Pregnancy & Lactation

At the recommended dosage in pregnancy, no harmful effect has been reported. Moreover, no embryotoxic or teratogenic effects on fetuses have been reported.

Drug Interaction

This combination should not be used with Pyrantel, morantel, and diethylcarbamazine.

OverDose

Triclabendazole 16 times and Levamisole 3 times safe than the recommended dosages.

Withdrawal Period

Storage

Keep in a cool and dry place, away from light. Keep out of the reach of children.

Commercial Pack

Duozol DS vet bolus: Each box contains 10 blisters strip of Alu-PVC of 2 boli.